Igf-I genetic variation and breast cancer: the multiethnic cohort.
نویسندگان
چکیده
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California; Program in Medical and Population Genetics, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts; Departments of Genetics, Medicine, and Pediatrics, Harvard Medical School; Department of Molecular Biology, Diabetes Unit, and Hematology-Oncology, Massachusetts General Hospital; Division of Genetics and Endocrinology, Children’s Hospital and Department of Pediatrics, Boston, Massachusetts; and Cancer Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, Hawaii
منابع مشابه
Haplotype-based association studies of IGFBP1 and IGFBP3 with prostate and breast cancer risk: the multiethnic cohort.
Collective evidence suggests that the insulin-like growth factor (IGF) system plays a role in prostate and breast cancer risk. IGF-binding proteins (IGFBP) are the principal regulatory molecules that modulate IGF-I bioavailability in the circulation and tissues. To examine whether inherited differences in the IGFBP1 and IGFBP3 genes influence prostate and breast cancer susceptibility, we conduc...
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Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California; Program in Medical and Population Genetics, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts; Departments of Genetics, Medicine, and Pediatrics, Harvard Medical School; Department of Molecular Biology, Diabetes Unit, and Hematology...
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Insulin-like growth factor (IGF)-I and IGF-II have been implicated in breast tumorigenesis due to their ability to stimulate mitogenesis and promote differentiation and their key role in mammary gland cell proliferation and survival (1-3). It has been reported that genetic variations in the gene encoding IGF-I are associated with levels of the protein and, as a consequence, may alter breast can...
متن کاملIGF-I and IGF-II genetic variation and breast cancer risk in Chinese women: results from the Shanghai Breast Cancer Study.
Insulin-like growth factor (IGF)-I and IGF-II have been implicated in breast tumorigenesis due to their ability to stimulate mitogenesis and promote differentiation and their key role in mammary gland cell proliferation and survival (1-3). It has been reported that genetic variations in the gene encoding IGF-I are associated with levels of the protein and, as a consequence, may alter breast can...
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The A-240T and I/D polymorphisms in the angiotensin I-converting enzyme (ACE) gene are markers of circulating ACE levels and have been associated with numerous cardiovascular disease outcomes. More recently, the low-activity A and I alleles at these polymorphic sites have been inversely related with breast cancer risk. We assessed the relationship between the A-240T and I/D ACE variants and bre...
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Rare, highly penetrant germ line mutations in BRCA1 strongly predispose women to a familial form of breast and ovarian cancer. Whether common variants (either coding or noncoding) at this locus contribute to the more common form of the disease is not yet known. We tested common variation across the BRCA1 locus in African American, Native Hawaiian, Japanese, Latino, and White women in the Multie...
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عنوان ژورنال:
- Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
دوره 15 1 شماره
صفحات -
تاریخ انتشار 2006